Our results support a genetic interaction between the VEGF-A rs3025039 and VEGFR-2 rs2071559 polymorphisms as a predictor of the risk to develop nodular goiter in subjects coming from an area with mild iodine deficiency.
Our results support a genetic interaction between the VEGF-A rs3025039 and VEGFR-2 rs2071559 polymorphisms as a predictor of the risk to develop nodular goiter in subjects coming from an area with mild iodine deficiency.
Subgroup analyses by type of disease revealed similar significant findings for rs1870377, rs2071559, and rs2305948 polymorphisms in coronary artery disease (CAD) subgroup.
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
Subgroup analyses by type of disease revealed similar significant findings for rs1870377, rs2071559, and rs2305948 polymorphisms in coronary artery disease (CAD) subgroup.
It was found that both rare homozygotes in the ANLN:rs12535394 and KDR:rs11133360 SNP pair are prognostic of favorable breast cancer survival and underpin the prominent roles of the immune response in cancer state control.
It was found that both rare homozygotes in the ANLN:rs12535394 and KDR:rs11133360 SNP pair are prognostic of favorable breast cancer survival and underpin the prominent roles of the immune response in cancer state control.
Significant G × E interactions were obtained for: rs1870377 with stress on total cholesterol (<i>p</i> = 0.035), low density lipoprotein cholesterol (<i>p</i> = 0.019), and apolipoprotein B100 (<i>p</i> = 0.004); and rs2071559 with anxiety on blood pressure (<i>p</i> = 0.006-0.045).
The rs1870377 KDR variant has shown association with RA under the codominant (<i>p</i> = 0.02, OR = 1.76, 95% CI = 1.09-2.85) and recessive models (<i>p</i> = 0.019, OR = 1.53, 95% CI = 1.07-2.20).
Our study suggested that the high expression of VEGFR-2, as well as the VEGFR-2 rs1870377 A > T genetic polymorphism, may be prognostic markers for GC.
Significant G × E interactions were obtained for: rs1870377 with stress on total cholesterol (<i>p</i> = 0.035), low density lipoprotein cholesterol (<i>p</i> = 0.019), and apolipoprotein B100 (<i>p</i> = 0.004); and rs2071559 with anxiety on blood pressure (<i>p</i> = 0.006-0.045).
Our study suggested that the high expression of VEGFR-2, as well as the VEGFR-2 rs1870377 A > T genetic polymorphism, may be prognostic markers for GC.
KDR rs2071559 T and rs2305948 A alleles were associated with RA (<i>p</i> = 0.001, OR = 0.60, 95% CI = 0.45-0.81 and <i>p</i> = 0.008, OR = 1.71, CI = 1.15-2.54).
Significant G × E interactions were obtained for: rs1870377 with stress on total cholesterol (<i>p</i> = 0.035), low density lipoprotein cholesterol (<i>p</i> = 0.019), and apolipoprotein B100 (<i>p</i> = 0.004); and rs2071559 with anxiety on blood pressure (<i>p</i> = 0.006-0.045).
Significant G × E interactions were obtained for: rs1870377 with stress on total cholesterol (<i>p</i> = 0.035), low density lipoprotein cholesterol (<i>p</i> = 0.019), and apolipoprotein B100 (<i>p</i> = 0.004); and rs2071559 with anxiety on blood pressure (<i>p</i> = 0.006-0.045).
KDR rs2071559 T and rs2305948 A alleles were associated with RA (<i>p</i> = 0.001, OR = 0.60, 95% CI = 0.45-0.81 and <i>p</i> = 0.008, OR = 1.71, CI = 1.15-2.54).
The study aimed to evaluate associations between shoulder pain/disability and seven single nucleotide polymorphisms (SNPs) within five angiogenesis-associated genes: <i>KDR</i> (rs2305948 C>T; rs7667298 C>T), <i>NOS3</i> (rs1549758 C>T), <i>MMP2</i> (rs708269 A>T), <i>THBS2</i> (rs9766678 A>G) and <i>TIMP3</i> (rs5754312 T>A; rs715572 G>A).
The study aimed to evaluate associations between shoulder pain/disability and seven single nucleotide polymorphisms (SNPs) within five angiogenesis-associated genes: <i>KDR</i> (rs2305948 C>T; rs7667298 C>T), <i>NOS3</i> (rs1549758 C>T), <i>MMP2</i> (rs708269 A>T), <i>THBS2</i> (rs9766678 A>G) and <i>TIMP3</i> (rs5754312 T>A; rs715572 G>A).
The purpose of this study was to evaluate the influence of selected polymorphisms in the genes coding for VEGF-A (+405 G/C, rs2010963; +936 C/T, rs3025039) and its receptor VEGFR-2 (+1416 T/A, rs1870377; -271 G/A, rs7667298) on the susceptibility to infantile hemangioma.